Ellie grew up as an orphan in the Boston quarantine zone and attended a military preparatory school, where she met and befriended Riley Abel. When Ellie was fourteen, the pair were both infected with the Cordyceps brain infection, where Ellie discovered she was immune.
A friend of her mother's and the leader of the Fireflies, Marlene, believed that she was the key to reverse engineering a vaccine. Marlene tasked Joel Miller, a smuggler, with escorting Ellie outside of the QZ. The simple drop-off turned into a year-long journey across America, and the two eventually formed a close bond.
Upon reaching the Fireflies in Salt Lake City, Joel learned that only killing Ellie could create the cure. Refusing to allow this, he killed the head surgeon and escaped with Ellie to settle down in Jackson, his brother's community in Wyoming. For the next four years, Ellie came to resent Joel for saving her life. In 2038, Abby Anderson, a former Firefly and the surgeon's daughter, found and killed Joel. Ellie vowed revenge and pursued Abby to Seattle.
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